Table: Predictive capacity- specificity and sensitivity- of EpiSkin, EpiDerm and RHE models. (a): Predictive capacity was established on 19 out of  20 reference test substances (heptanal: not tested). (b): Evaluation of the second endpoint (IL-1α) was performed only by Zebet ‘Laboratory demonstrating that the increase in sensitivity was achieved by severe loss in specificity (Hoffmann S., 2006)