Introduction:Recent developments at SkinEthic Laboratories.
Bart De Wever, Director Business Development SkinEthic Laboratories, France.

Molecular mechanisms of skin irritation: use of reconstructed human skin models to predict irritant potential of substances.
Dr. Thomas Welss, Manager COLIPA Research Project, Henkel, Germany.

Background of adverse effects and need for dermal irritancy assessment as part of hazard identification, communication and control strategies.
Dr. Chris Seaman, Manager Occupational Toxicology, GlaxoSmithKline, UK.

In vitro reconstruction of human epidermis: adequate culture conditions produce an adequate tissue.
Prof. Yves Poumay, Department of Embryology, University of Namur, Belgium.

Drug effects measured by a novel tool for skin immuno-pharmacology: organotypical skin-whole blood co-cultures.
Dr. Manfred Schmolz, Dept. of Experimental & Diagnostical Immunology, EDI GmbH, Germany.

Global gene expression analysis greatly widens the applicability of cultured human cell lines to biomedical research: the oral epithelium as an example.
Prof. Roland Grafström, Experimental

Characterization of human oral and gingival mucosal models: a histological characterization and applications in toxicity testing.
Dr. Bart Vande Vannet & Dr. Jean-Louis Hanssens, Faculty of Medicine, Pharmacology & Dentistry, Free University of Brussels, Belgium.

Characterization of the immune response in in vitro models of candidosis based on reconstituted human epithelium.
Dr. Martin Schaller, University of Tübingen, Germany.

Outcome of the validation study with the SkinEthic Reconstituted Human Epidermis for skin corrosion testing according to OECD guideline 431.
Dipl. Ing. Helena Kandarova, Ph.D. Student in vitro models for skin irritation and corrosivity testing, ZEBET, Germany.

Human skin models for testing cutaneous absorption: results of the German pre-validation study.
Prof. Monika Schäfer-Korting, Vice Dean, Free University of Berlin, Germany.

Assessment of the Skin Irritation Potential of Chemicals using the SkinEthic Reconstituted Human Epidermis.
Dipl. Ing. Helena Kandarova, Ph.D. Student in vitro models for skin irritation and corrosivity testing, ZEBET, Germany.

Safety evaluation of chemicals using human reconstituted epidermis models.
Dr. Kirstin Meyer, Schering, Germany.


An assessment of the irritant effects (skin and eye) of a range of preservatives, cosmetic and paint formulations using the SkinEthic models.
Dr. Bruce Alexander, Thor, UK.

Reconstituted human corneal epithelial model: successful pre-validation for the assessment of the eye irritation potential of chemicals.
Dr. Els Adriaens, Post-Doc Pharmaceutical Technology, University of Ghent, Belgium.

Initial assessment of the SkinEthic human corneal epithelial model for the occupational hazard assessment of pharmaceutical process materials.
Dr. Robert Guest, Manager Alternative Methods, Safepharm Laboratories, UK.

Recent advances in the development and characterization of a biologically standardized human Full Thickness skin model for in vitro toxicology & pharmacology testing.
Dr. Florent Sahuc, R&D Manager, SkinEthic Laboratories, France.

Evidence for DNA protection and repair: a kinetic study.
Dr. Isabelle Imbert, Exsymol, Monaco.

Workshop Closing Remarks & Round Table Discussion.
Pr. Alan M. Goldberg, John Hopkins University, Bloomberg School of Public Health, Baltimore, USA.